Francis Jerdone was born in Jedbury, Scotland in 1721, the son of John Jerdone, a magistrate and treasurer of the town. At the age of nineteen, in 1752, he immigrated to Virginia and settled in Hanover County, Yorktown; and Louisa County. He made his living as a merchant (factor), running a mercantile business. In the 1730’s, Glasgow merchants had begun sending factors to live in Virginia, buy tobacco and sell goods. Jerdone died in 1771.